Series ‘‘signalling and Transcriptional Regulation in Inflammatory and Immune Cells: Importance in Lung
نویسنده
چکیده
Substantial experimental evidence now supports the notion that allergic diseases are characterised by a skewing of the immune system towards a T-helper cell type-2 (Th2)
منابع مشابه
Series ‘‘signalling and Transcriptional Regulation in Inflammatory and Immune Cells: Importance in Lung
The aim of this review is to discuss recent advances in the understanding of the regulation of chemokine expression occurring during chronic inflammatory conditions, such as allergic diseases. The focus will be on current data, which suggest that post-transcriptional regulation plays a larger role in chemokine gene regulation than previously recognised. In particular, a growing body of data ind...
متن کاملI-34: Steroid Hormone Signalling at the FetomaternalInterface
Background: Progesterone is indispensable for differentiation of human endometrial stromal cells (HESCs) into decidual cells, a process that critically controls embryo implantation. However, HESCs also abundantly express androgen receptors (AR), yet the role of this member of the superfamily of ligand-dependent transcription factors in the decidual process remains poorly elucidated. Materials a...
متن کاملSignalling and transcriptional regulation in inflammatory and immune cells: importance in lung biology and disease.
L iving cells respond to their external environment and to signals from other cells by transducing these signals to different parts of the cell, particularly to the nucleus. This idea was initiated by RALL and SUTHERLAND [1], with the concept of cyclic adenosine monophosphate acting as a second messenger to mediate the action of the first messenger that arrived at the cell surface. Much of cell...
متن کاملSeries ‘‘signalling and Transcriptional Regulation in Inflammatory and Immune Cells: Importance in Lung
b2-Adrenoceptor agonists evoke rapid bronchodilatation and are the mainstay of the treatment of asthma symptoms worldwide. The mechanism of action of this class of compounds is believed to involve the stimulation of adenylyl cyclase and subsequent activation of the cyclic adenosine monosphosphate (cAMP)/cAMP-dependent protein kinase cascade. This classical model of b2-adrenoceptor-mediated sign...
متن کاملThe Full Length Hepatitis C Virus Polyprotein and Interactions with the Interferon-Beta Signalling Pathways in vitro
Background: Hepatitis C is a global health problem. The exact mechanisms by which hepatitis C virus (HCV) can evade the host immune system have become controversial. Whether HCV polyproteins modulate IFN signalling pathways or HCV proteins are responsible for such a property is the subject of interest. Therefore, an efficient baculovirus delivery system was developed to introduce the whole geno...
متن کامل